The cost of long term therapy for gastro-oesophageal reflux disease: a randomised trial comparing omeprazole and open antireflux surgery

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The cost of long term therapy for gastro-oesophageal reflux disease: a randomised trial comparing omeprazole and open antireflux surgery.

BACKGROUND AND AIM To comprehensively assess the relative merits of medical and surgical therapy for gastro-oesophageal reflux disease (GORD), health economic aspects have to be incorporated. We have studied the direct and indirect costs of medical and surgical therapy within the framework of a prospective randomised multicentre trial. METHODS After initial treatment of reflux oesophagitis wi...

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GASTRO-OESOPHAGEAL REFLUX DISEASE Endoscopic gastroplication for the treatment of gastro- oesophageal reflux disease: a randomised, sham-controlled trial

Background: Endoscopic treatment for gastro-oesophageal reflux disease (GORD) is rapidly emerging, but there is a great need for randomised controlled trials to evaluate the efficacy. Design and setting: A single-centre, double-blind, randomised, sham-controlled trial of endoscopic gastroplication by the Endocinch suturing system. Patients and interventions: 60 patients with GORD were randomly ...

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Omeprazole for asthma with gastro-oesophageal reflux.

I would like to congratulate POSTMA and coworkers [1] for their placebo-controlled study on the effects of highdose omeprazole in patients with severe hyperresponsiveness and gastro-oesophageal reflux (GOR). Previously published reports of the effects of medical antireflux therapy in asthma have claimed effects ranging from improvements in lung function [2], asthma medication requirements, and ...

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GASTRO-OESOPHAGEAL REFLUX Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease

Background: Transient lower oesophageal sphincter relaxation (TLOSR) is the predominant mechanism of gastro-oesophageal reflux (GOR) in healthy infants but the mechanisms of GOR in infants with GOR disease (GORD) are poorly understood. Aims: To measure the occurrence of TLOSR, GOR, and gastric emptying (GE) rate in preterm and term infants with GORD. Patients: Thirty six infants were studied an...

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Evaluation of omeprazole as a cost-effective diagnostic test for gastro-oesophageal reflux disease.

BACKGROUND There is a need for a simple, therapeutic test that is of diagnostic value and can also provide rapid symptom relief in patients who present with classic, mild symptoms suggestive of gastro-oesophageal reflux disease (GERD), when the diagnosis is based on symptom assessment alone. AIM To assess the diagnostic value of a therapeutic trial of omeprazole 40 mg in a dyspeptic populatio...

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ژورنال

عنوان ژورنال: Gut

سال: 2001

ISSN: 0017-5749

DOI: 10.1136/gut.49.4.488